Expansion of Genomics Applications
from Research Bench to Patient Bedside Enabled by Genomic Solutions’
Superior Arraying Quality
DNA and protein microarrays printed on glass or membrane-coated
microscope slides have been widely used in scientific research over
the past decade. This approach has provided researchers with the
opportunity to investigate thousands of gene sequences or proteins
in a single experiment.
With technology advances and quality improvements associate with
almost every step of the microarray process, and the increasing
amount of knowledge obtained from gene expression analysis, microarray
is quickly expanding from being just a research tool. Recently,
companies like Combimatrix Molecular Diagnostics, a CLIA-certified,
CAP-accredited commercial clinical laboratory, began to use microarray
in diagnostic environment and help physicians to make better treatment
decisions and improve patient outcomes.
Genomic Solutions have been the market leader in DNA and protein
microarraying. We provide high quality microarrayers—MicroGrid II
and OmniGrid Accent, to suite different throughput needs from our
customers.
MicroGrid |
OmniGrid® Accent
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In addition to printing arrays on microscopic slides, we now offer
the capability to multiplex array experiments by printing microarrays
into the wells of microtiter plate wells.
Hardware and software upgrades are available for both MicroGrid
II and OmniGrid Accent, allowing users currently printing on slides
to easily convert to plate arraying. In addition, it is very easy
to switch between the two applications; a useful feature for core
laboratories with multiple customers performing different types
of assays. The following is an example of array at the bottom of
microtiter plate:
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Over 1300 array spots printed at the bottom
of a single well of a 96-well microtiter plate
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Regardless of printing array on slides or in plates, spot quality
is the key. Our arrayers have been the reliable production tool
of choice by the core facilities in almost all major genome centers
over the world and many commercial companies.
The following is an illustration of the high-quality CA1000 BAC
CGH array from Combimatrix Molecular Diagnostics, using our MicroGrid
II instrument. It demonstrates that our arrayers are capable of
producing microarrays with superior quality, suitable for diagnostic
use in CLIA-certified, CAP-accredited environment.
For a demonstration of our microarray instruments and advice on
microarray applications, please contact us at: arraydesign@genomicsolutions.com